Valeria Martin – Curcumin: Clinical Uses, Health Effects and Potential Complications

Curcumin is a natural product with polyphenolic structure. It is used in therapeutic remedies alone or in combination with other natural substances. Many researchers are investigating it because of its biologicalactivities such as: anti-inflammatory, anti-cancer, anti-protozoal, anti-viral, anti-bacterial and has been found to be effective for treatment of Alzheimer, depression, headaches, fibromyalgia, leprosy, fever, menstrual problems, water retention, worms and kidney problems etc. It is an active ingredient in dietary spice, turmeric. It has reactive functional groups: a diketone moiety and two phenolic groups. Despite its unique biological activities, it suffers from some shortcomings which include: gastrointestinal problems, poor bioavailability due to its poor absorption, short half-life, poor solubility in aqueous solutions, rapid systemic elimination and antithrombotic activity which can interfere with blood clotting. The first chapter of this book reviews the different delivery systems used for incorporation of curcumin and its derivatives, release kinetics and up to date in vivo results. Chapter two discusses curcumin nano and microencapsulation and its implications on clinical uses. Chapter three studies the effect of curcumin in nasal epithelial cells. The last two chapters studies the epigenetic changes induced by curcumin and its congeners and the potential of utilizing these changes in the treatment of different diseases; and examines differential absorption of curcuminoids between free and liposomed curcumin formulations. Table of Contents:Prefacepp. vii-xChapter 1An Overview of Nano-Based Formulations of Curcumin and its Derivatives(B. A. Aderibigbe, T. Naki and A. Mugogodi, Department of Chemistry, University of Fort Hare, Alice Campus, Eastern Cape)pp. 1-24Chapter 2Curcumin Nano and Microencapsulation and its Implications on Clinical Uses(Jéssica T. P. Silva, Anderson C. da Silva, Bruno A. da Rocha, Lívia Bracht, Ciomar A. B. Amado, Fernanda V. Leimann, Odinei H. Gonçalves, Post-Graduation Program of Food Technology – Federal University of Technology – Paraná, Via Rosalina Maria dos Santos, Campo Mourão – PR, Brazil, and others)pp. 25-64Chapter 3The Effects of Curcumin in Human Nasal Epithelial Cells(Kenichi Takano, Kazufumi Obata, Tetsuo Himi and Takashi Kojima, Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan, and others)

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